The  effects of heavy metals on the developing brain

Anatoly Nikolaevich Inozemtsev; Ulduz Faizi Hashimova; Khadija Yusif Ismayilova; Olga Vecheslavovna Karpukhina; Yelena Anatolevna Inozemtsev Fermin; Farkhad Elkhan Rustamov; Rashad Ibrahim Ibrahimov

doi:10.59883/ajp.5

Vol. 37 No. 1 (2022), REVIEWS

Vol. 37 No. 1 (2022)

The effects of heavy metals on the developing brain

REVIEWS

https://doi.org/10.59883/ajp.5

Published 2022-06-14

Anatoly Nikolaevich Inozemtsev ⁺⁻
Ulduz Faizi Hashimova⁺⁻
Khadija Yusif Ismayilova⁺⁻
Olga Vecheslavovna Karpukhina⁺⁻
Yelena Anatolevna Inozemtsev Fermin⁺⁻
Farkhad Elkhan Rustamov⁺⁻
Rashad Ibrahim Ibrahimov⁺⁻

Anatoly Nikolaevich Inozemtsev

Lomonosov Moscow State University

https://orcid.org/0000-0002-5059-3241

Ulduz Faizi Hashimova

Academician Abdulla Garayev Institute of Physiology

https://orcid.org/0000-0002-7740-0972

Khadija Yusif Ismayilova

Academician Abdulla Garayev Institute of Physiology

Olga Vecheslavovna Karpukhina

Lomonosov Moscow State University

https://orcid.org/0000-0002-4642-8366

Yelena Anatolevna Inozemtsev Fermin

Lebanese International University

Farkhad Elkhan Rustamov

Academician Abdulla Garayev Institute of Physiology

Rashad Ibrahim Ibrahimov

Azerbaijan Medical University

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Keywords

heavy metals
developing brain
stress
neurotropic agents
learning
memory

How to Cite

1.

Inozemtsev AN, Hashimova UF, Ismayilova KY, Karpukhina OV, Inozemtsev Fermin YA, Rustamov FE, Ibrahimov RI. The effects of heavy metals on the developing brain. Azerbaijan Journal of Physiology. 2022;37(1):7-16. doi:10.59883/ajp.5

Abstract

The present paper reviews the works on the combined effects of heavy metals (HMs) with other HMs, stress, and neurotropic drugs on the developing central nervous systems of humans and animals performed over the past 30 years. The analysis shows that there are disproportionately few works on the mentioned joint effects of HMs in relation to the importance of this issue. It was found that the joint administration of HMs with each other and under stress increases the neurotoxic effect of metals on the brain of animals. A greater vulnerability to the neurotoxic effects of HM mixtures on the developing brain was also noted. Neurotropic drugs in combination with HMs have multidirectional effects. Thus, along with the counteraction of the reference nootropic piracetam to the inhibition of the avoidance response in rats, which is exerted by HMs, there was an increase in the neurotoxic effects of lead and cadmium salts when combined with that nootropic. Combined administration of Semax (a regulatory peptide with nootropic effects) and molybdenum, which separately suppressed the avoidance response in rats, paradoxically improved learning and memory. The revealed unpredictability and enhancement of the neurotoxic effects of HMs when combined with neurotropic agents are fraught with danger to human health in regions with developed industries. This is especially important for the health of children due to the increased vulnerability of their developing brains to neurotoxicants.

https://doi.org/10.59883/ajp.5

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