The purpose of this study was to study the effect of chronic poisoning with nickel nitrate in experimental atherosclerosis on the state of anxiety in the «elevated plus maze» test. The experiments were carried out on 50 white non-linear male rats. The model of atherosclerosis was created according to I.V. Savitsky et al. (2016), which is based on the polyetiological theory of the development of the disease. After modeling atherosclerosis, poisoning with nickel nitrate was carried out through the drinking water for 60 days at a dose of 2 mg/kg.
The results showed that the behavioral disturbances that occurred after the modeling of atherosclerosis were aggravated after poisoning with nickel nitrate. In particular, in the «elevated plus maze» test, adequate parameters visually reflecting the state of anxiety were manifested in active avoidance of the open space of the maze, in a decrease in the number of vertical stands, in a decrease in the number of hanging from open sleeves, in a decrease the number of looks from closed sleeves, as well as in a decrease the number of grooming with a corresponding increase in its duration. Maximum disturbances were observed two months after exposure to nickel nitrate. The obtained data show a toxic neurotropic effect of chronic intoxication with nickel nitrate in experimental atherosclerosis and dictate the need to develop effective correction methods in the clinic chronic poisoning with nickel nitrate, which is especially important for the category of older age people groups and patients with atherosclerotic lesions vessels.
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