A study of lipid metabolism and oxidative stress in rats with chronic nickel nitrate poisoning in the background of experimental atherosclerosis under the influence of a complex antitoxicant


plant antitoxicant
lipid metabolism
oxidative stress
nickel nitrate
experimental atherosclerosis

How to Cite

Ibrahimov RI, Hashimova UF, Ismayilova KY. A study of lipid metabolism and oxidative stress in rats with chronic nickel nitrate poisoning in the background of experimental atherosclerosis under the influence of a complex antitoxicant. Azerb. J. Physiol. 2022;37(2):13-19. doi:10.59883/ajp.27


The purpose of the research was to study the effect of a complex plant antitoxicant from the flora of Azerbaijan consisting of a mixture of licorice, wild rose, grape seeds, oat bran, and burdock in a ratio of 3:2:1:1:2 (Eurasian patent 201600043 dated 06/25/2018) on lipid metabolism and oxidative stress in rats chronically poisoned with nickel nitrate against the background of experimental atherosclerosis. It was shown that in experimental atherosclerosis, after exposure to nickel nitrate, lipid metabolism and oxidative stress disorders were aggravated. A proportional relationship was found between the severity of disorders and the duration of intoxication with nickel nitrate, with a maximum of disorders on the 60th day after exposure. In the experimental group, after chronic intoxication with nickel nitrate, a complex plant antioxidant implementation led to a significant improvement in lipid metabolism and oxidative stress. The revealed corrective effect of the plant antitoxicant indicates its detoxifying effect and the possibility of its clinical approbation both for the prevention and treatment of chronic nickel nitrate poisoning in patients with existing atherosclerotic vascular lesions.



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