A study of lipid metabolism and oxidative stress in rats with chronic nickel nitrate poisoning in the background of experimental atherosclerosis under the influence of a complex antitoxicant

Rashad Ibrahim Ibrahimov; Ulduz Faizi Hashimova; Khadija Yusif Ismayilova

doi:10.59883/ajp.27

Vol. 37 No. 2 (2022), EXPERIMENTAL PHYSIOLOGY

Vol. 37 No. 2 (2022)

A study of lipid metabolism and oxidative stress in rats with chronic nickel nitrate poisoning in the background of experimental atherosclerosis under the influence of a complex antitoxicant

EXPERIMENTAL PHYSIOLOGY

https://doi.org/10.59883/ajp.27

Published 2022-12-30

Rashad Ibrahim Ibrahimov⁺⁻
Ulduz Faizi Hashimova⁺⁻
Khadija Yusif Ismayilova⁺⁻

Rashad Ibrahim Ibrahimov

Azerbaijan Medical University

Ulduz Faizi Hashimova

Academician Abdulla Garayev Institute of Physiology

https://orcid.org/0000-0002-7740-0972

Khadija Yusif Ismayilova

Academician Abdulla Garayev Institute of Physiology

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Keywords

plant antitoxicant
lipid metabolism
oxidative stress
nickel nitrate
experimental atherosclerosis

How to Cite

1.

Ibrahimov RI, Hashimova UF, Ismayilova KY. A study of lipid metabolism and oxidative stress in rats with chronic nickel nitrate poisoning in the background of experimental atherosclerosis under the influence of a complex antitoxicant. Azerb. J. Physiol. 2022;37(2):13-19. doi:10.59883/ajp.27

Abstract

The purpose of the research was to study the effect of a complex plant antitoxicant from the flora of Azerbaijan consisting of a mixture of licorice, wild rose, grape seeds, oat bran, and burdock in a ratio of 3:2:1:1:2 (Eurasian patent 201600043 dated 06/25/2018) on lipid metabolism and oxidative stress in rats chronically poisoned with nickel nitrate against the background of experimental atherosclerosis. It was shown that in experimental atherosclerosis, after exposure to nickel nitrate, lipid metabolism and oxidative stress disorders were aggravated. A proportional relationship was found between the severity of disorders and the duration of intoxication with nickel nitrate, with a maximum of disorders on the 60th day after exposure. In the experimental group, after chronic intoxication with nickel nitrate, a complex plant antioxidant implementation led to a significant improvement in lipid metabolism and oxidative stress. The revealed corrective effect of the plant antitoxicant indicates its detoxifying effect and the possibility of its clinical approbation both for the prevention and treatment of chronic nickel nitrate poisoning in patients with existing atherosclerotic vascular lesions.

https://doi.org/10.59883/ajp.27

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