Keywords
lateral geniculate body
visual cortex
evoked potentials
retinal dystrophy
curcumin
How to Cite
Abstract
The rehabilitative curcumin effect on the visual system function was investigated in studies conducted on awake unanesthetized rabbits. Analysis of the results obtained showed that after curcumin administration, certain changes in the evoked activity of the retina, superior colliculus, lateral geniculate body and primary visual cortex were observed in the model of retinal dystrophy. The neuronal apparatus of the glial layer of the retina damaged in moderate retinal dystrophy led to functional disintegration of the mechanisms of electrogenesis. The curcumin administration led to an increase in the amplitude parameters of evoked potentials in all structures. The most pronounced curcumin effect was observed in the potentials of the visual cortex evoked by light stimuli, where certain changes in the configuration of evoked responses were noted.
References
Блинков СМ, Бразовсквя ФА. Атлас мозга кролика. М.: Медицина; 1973, 27 с. [Blinkov SM, Brazovskaya FA. Atlas of the rabbit’s brain. Moscow: Medicine; 1973, 27 p.]
Бирич ТА, Марченко ЛН, Чекина АЮ. Офтальмология. Москва: Вышэйшая школа; 2015, 576 c. [Birich TA, Marchenko LN, Cekina AY. Ophthalmology. Moscow: Vyshejshaya shkola; 2015, 576 p.]
Shehzad A, Wahid F, Sup YL. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 2010 Sep;343(9):489-99. https://doi.org/10.1002/ardp.200900319
Ak T, Gülçin İ. Kurkuminin antioksidan və radikal təmizləyici xüsusiyyətləri. Kimya. Biol. Qarşılıqlı əlaqə. 2008;174:27-37. https://doi.org/10.1016/j.cbi.2008.05.003
Ak T, Gulçin İ. Antioxsidant and radical scavenging properties of curcumin Chem. Bio. Interact, 2008, 174 :27–37.]
Daniel-M, Villarón-Casares A, Jiménez A, Miranda M, Llopis D, Romero F, and Vincent V. Curcumin as a therapeutic option in retinal diseases. Antioxidants (Basel). 2020 Jan;9(1):48. https://doi.org/10.3390/antiox9010048
Daverey A, Agrawal S.K. Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk. Journal of Neurotrauma, 2020, May 15;37(10):1255-1265. https://doi.org/10.1089/neu.2019.6749.
Khajavi M, Inoue K, Wiszniewski W, Ohyama T, Snipes GJ, Lupski JR. Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants. Am J Hum Genet. 2005 Nov;77(5):841-50. https://doi.org/10.1086/497541
Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, Wicker L, Kasus-Jacobi A, Elliott MH, Rao CV, Anderson RE. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med. 2009 Mar 1;46(5):672-9. https://doi.org/10.1016/j.freeradbiomed.2008.12.006
Muangnoi C, Sharif U, Ratnatilaka Na Bhuket P, Rojsitthisak P, Paraoan L. Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H2O2-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells: Potential Therapeutic Avenues for Age-Related Macular Degeneration, Molecular Biology of Age-Related Macular Degeneration, Sci. 2019;20(13):3367. https://doi.org/10.3390/ijms20133367.
Peddada KV, Brown A, Verma V, Nebbioso M. Therapeutic potential of curcumin in major retinal pathologies. Int Ophthalmol. 2019 Mar;39(3):725-734. https://doi.org/10.1007/s10792-018-0845-y.
Woo J.M., Shin D.Y., Lee S.J., Joe Y., Zheng M., Yim J.H., Callaway Z., Chung H.T. Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen. Molecular vision. 2012;8:901-908.
Zhu W., Wu Y., Meng Y.F., Wang J.Y., Xu M., Tao J.J., Lu J. Effect of curcumin on aging retinal pigment epithelial cells. Drug Des Development and Therapy. 2015;9:5337-5344. https://doi.org/0.2147/DDDT.S84979.
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