Nowadays, depression is referred to psychiatric disease and is widely spread throughout the world. The pathogenesis of depression in humans is characterized by significant disturbances of serotonin turnover and its downregulation in brain structures. The objective of the present study was the definition of the levels of serotonin-modulating anticonsolidation protein (SMAP) and dihydropyrimidinase-related protein 2 (DRP2) in the brain amygdala, platelets, and to anti-SMAP natural autoantibodies in the depression Wistar rats of both sexes. A depression state in the rats was formed in the dominant model and its successful formation was confirmed in the forced swimming test by the decreased timeframe of active swimming. Through the application of an indirect ELISA test in the depressive male and female rats, a downregulation of SMAP and DRP2 in the amygdala, an upregulation of SMAP in the platelets of depressive male rats, a noticeable downregulation of DRP2 in the platelets of depressive female rats, and a sharp downregulation of anti-SMAP natural autoantibodies in the serum of depressive male rats were observed.
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