The changes of serotonin-modulating anticonsolidation protein and dihydropyrimidinase-related protein 2 in the amygdala and blood of depressive rats
Keywords:
depression, male and female rats, indirect ELISA test, amygdala, platelets, SMAP, serotonin-modulating anticonsolidation protein, DRP2, dihydropyrimidinase-related protein 2, anti-SMAP natural autoantibodiesAbstract
Nowadays depression is referred to psychiatric disease and is widely spread throughout the world. Pathogenesis of depression in humans is characterized by significant disturbances of serotonin turnover and its downregulation in the brain structures. The objective of the present study was the definition of the levels of serotonin-modulating anticonsolidation protein (SMAP) and dihydropyrimidinase-related protein 2 (DRP2) in the brain amygdala, platelets and of anti-SMAP natural autoantibodies in the depression Wistar rats of both sexes. A depression state in the rats was formed in the dominant model and its successful formation was confirmed in the forced swimming test by the decreased timeframe of active swimming. Through the application of an indirect ELISA test in the depressive male and female rats a downregulation of SMAP and DRP2 in the amygdala, upregulation of SMAP in the platelets of depressive male rats and noticeable downregulation of DRP2 in the platelets of depressive female rats, and sharp downregulation of anti-SMAP natural autoantibodies in the serum of depressive male rats was observed.
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