Comparative analysis of the effect of precursors of biogenic amines on the projection areas of the cerebral cortex
Azerbaijan Journal of Physiology
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Keywords

visual cortex
sensorimotor cortex
serotonin precursor 5-HTF
noradrenaline precursor L-DOPA
left and right cerebral cortex
bioelectric potential

How to Cite

1.
Hasanova LH. Comparative analysis of the effect of precursors of biogenic amines on the projection areas of the cerebral cortex. Azerbaijan Journal of Physiology. 2022;37(1):38-44. doi:10.59883/ajp.13

Abstract

This work was conducted on rabbits in chronic studies. EEG activity of the left and right sides of the visual and sensory cortex of the brain of animals was registered with the use of steel needle electrodes before, during, and after the introduction of precursors of biogenic amines:  5‑hydroxytryptophan (5-HTF) and L-Dioxyphenylalanine (L-DOPA). The program of the experiment studied the effect of the total activity of the right and left visual and sensory-motor cortex during the exogenous introduction of 35-40 mg/kg of the precursor of serotonin (5-HTF) and 45-50 mg/kg of the precursor of norepinephrine (L-DOFA). The results of the analysis of the correlogram showed that an increase in the observed reactions was observed by their regulation. However, at the beginning of the effect of the substance, the cross-correlation values were lower, but then they quickly increased in the sensorimotor and visual fields and reached maximum on both sides of visual acuity. Both studied monoamine precursors, 5-HTF and L-DOFA, had specific reactions in the EEG-activity of the cerebral cortex. This was more apparent in the visual cortex

https://doi.org/10.59883/ajp.13
PDF (Azərbaycan dili)

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